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methylprednisolone will lessen the level or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.bosentan will decrease the level or influence of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Coadministration of encorafenib with sensitive CYP3A4 substrates